hsa-miR-122-5p

By admin , 16 September 2025
Go ontology
Literature evidence
Literature link GPT Summary Evidence category Disease type
35926094 This study aimed to identify and validate differentially expressed miRNAs in plasma exosomes from women with GDM and those with NGT. Using high-throughput sequencing and real-time qPCR, the researchers found 22 exosomal miRNAs, with five significantly altered miRNAs (miR-423–5p, miR-122–5p, miR-148a-3p, miR-192–5p, and miR-99a-5p). These miRNAs are involved in insulin and AMPK signaling pathways, suggesting their role in metabolic regulation in GDM. The five miRNAs showed a high accuracy (AUC=0.82) in predicting GDM early.
 Risk factor
 GDM
31058973 The study aimed to explore the role of placenta-derived miRNAs in the development of GDM by comparing miRNA expression in EVs from the serum of women who developed GDM and healthy controls during early pregnancy. The researchers found that ten miRNAs, including hsa-miR-122-5p, had significantly higher levels in GDM cases compared to controls, suggesting that these miRNAs could play a role in the pathophysiology of GDM and offer a potential biomarker for early diagnosis. Risk factor GDM
Other information links
miRBase
MIMAT0000421
KEGG pathway
Cholinergic synapse, GABAergic synapse, Dilated cardiomyopathy, Glucagon signaling pathway, Circadian entrainment, HIF-1 signaling pathway, Thyroid cancer, Adherens junction, JAK-STAT signaling pathway, Notch signaling pathway, Carbohydrate digestion and absorption, Calcium signaling pathway, Fat digestion and absorption
Relationship with GDM:
hsa-miR-122-5p
Figure's link
35926094
Expressing in plasma exosomes:
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RF's name
hsa-miR-122-5p
RF's type
miRNA