hsa-miR-20a-5p

By admin , 16 September 2025
Go ontology
Literature evidence
Literature link GPT Summary Evidence category Disease type
25887942 This study used next-generation sequencing to identify differentially expressed miRNAs in maternal plasma during early pregnancy, focusing on those associated with GDM. It found 32 miRNAs that were differentially expressed, with five being validated by qRT-PCR. These miRNAs are linked to insulin resistance and abnormal pregnancies, suggesting their potential as noninvasive biomarkers for early diagnosis of GDM. Risk factor GDM
29556924 The study investigates the regulation of serum miRNAs in South African women with gestational diabetes mellitus (GDM), focusing on miRNAs previously linked to GDM in other populations. It found that miR-20a-5p and miR-222-3p were significantly downregulated in GDM patients. Logistic regression analysis indicated that miR-20a-5p and additional risk factors predict GDM. Functional analysis suggests miR-20a-5p's involvement in metabolic pathways, particularly insulin signaling. While miR-20a-5p shows promise as a biomarker for GDM, it may require incorporation into broader miRNA panels for improved specificity. Risk factor GDM
Other information links
miRBase
MIMAT0000075
KEGG pathway
Cholinergic synapse, GABAergic synapse, Dilated cardiomyopathy, Glucagon signaling pathway, Circadian entrainment, HIF-1 signaling pathway, Thyroid cancer, Adherens junction, JAK-STAT signaling pathway, Notch signaling pathway, Carbohydrate digestion and absorption, Calcium signaling pathway, Fat digestion and absorption
Relationship with GDM:
hsa-miR-20a-5p
Figure's link
29556924
Expressing in serum:
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RF's name
hsa-miR-20a-5p
RF's type
miRNA