ADPN

This study found that low maternal plasma adiponectin levels are significantly associated with an increased risk of gestational diabetes mellitus (GDM). In a nested case-control study of 41 GDM cases and 70 controls, women with GDM had significantly lower adiponectin concentrations (4.4 vs. 8.1 μg/mL, *P* < 0.001). Adiponectin levels below 6.4 μg/mL were observed in 73% of GDM cases versus 33% of controls. After adjusting for confounding factors, women with low adiponectin had a 4.6-fold increased risk of GDM (95% CI: 1.8-11.6). These findings, consistent with associations seen in type 2 diabetes, suggest that hypoadiponectinemia is a strong predictor of GDM and highlight the need for further research on interventions to modulate adiponectin levels.