Disease's type
GDM
Experimental grouping
HbA1c<5.7%,GDM(n=14),Normal Glucose Tolerance(n=251); HbA1c 5.7-6.4%=55,GDM(n=5),Normal Glucose Tolerance(n=27)
GPT's summary
This study assessed whether an early hemoglobin A1c (HbA1c) value of 5.7–6.4% could predict the progression to gestational diabetes mellitus (GDM). Among women screened before 20 weeks of gestation, 27.3% of those with HbA1c levels of 5.7–6.4% developed GDM, compared to 8.7% with HbA1c <5.7% (odds ratio: 3.9; adjusted odds ratio: 2.4). The increased risk remained significant after adjusting for multiple confounders. However, no significant differences were observed in maternal weight gain, delivery route, birthweight, or neonatal morbidities between the groups. The findings suggest that women with an HbA1c of 5.7–6.4% should receive closer monitoring and potential early intervention for GDM prevention.
RF's name
Hemoglobin A1c
Sample's type
Whole Blood
Gestational weeks
before 20th gestational weeks
Experiemental methods
Ion-Exchange High Performance Liquid Chromatography(Ion-Exchange HPLC)
Title
Use of hemoglobin A1c as an early predictor of gestational diabetes mellitus
Evidence's type
Risk factor
Year
2014
Journal
American Journal of Obstetrics And Gynecology
PMID