Disease's type
GDM
Experimental grouping
HbA1c < 5.2%:GDM(n=568),Normal Glucose Tolerance(n=3863),5.9%< HbA1c <6.4%, GDM(n=124),Normal Glucose Tolerance(n=69),HbA1c ≥ 6.5%, GDM(n=16),Normal Glucose Tolerance(n=2)
GPT's summary
This study investigated the optimal HbA1c threshold for detecting undiagnosed diabetes in early pregnancy and its association with adverse pregnancy outcomes. Among 16,122 women tested at a median of 47 days' gestation, an HbA1c ≥5.9% (41 mmol/mol) identified all diabetes cases detected by an early oral glucose tolerance test (OGTT) performed before 20 weeks, including those with HbA1c below the standard 6.5% (48 mmol/mol) cutoff. Women with HbA1c levels of 5.9–6.4% had significantly increased risks of major congenital anomalies, preeclampsia, shoulder dystocia, and perinatal death compared to those with HbA1c below 5.9%. The findings suggest that HbA1c ≥5.9% in early pregnancy is a practical and effective marker for identifying women at high risk of diabetes and adverse outcomes, emphasizing its value for early intervention.
RF's name
Hemoglobin A1c
Sample's type
Whole Blood
Gestational weeks
before 12th gestational weeks
Experiemental methods
Ion-Exchange High Performance Liquid Chromatography(Ion-Exchange HPLC)
Title
An early pregnancy HbA1c ≥5.9% (41 mmol/mol) is optimal for detecting diabetes and identifies women at increased risk of adverse pregnancy outcomes
Evidence's type
Risk factor
Year
2014
Journal
Diabetes Care
PMID