SF

This study investigated the relationship between serum ferritin levels and the risk of gestational diabetes mellitus (GDM), insulin resistance (IR), and gestational hypertriglyceridemia (GTG) in 781 pregnant women. Participants were divided into quartiles based on serum ferritin levels. Compared to the lowest quartile (Q1), higher serum ferritin levels (Q3 and Q4) were significantly associated with an increased risk of GDM (OR = 1.79 for Q3 and OR = 2.07 for Q4) and insulin resistance (OR = 2.18 for Q3 and OR = 3.14 for Q4), even after adjusting for age and pre-pregnancy BMI. However, no significant association was found between serum ferritin levels and GTG, although triglyceride levels were positively correlated with ferritin in the second trimester. The study concludes that elevated serum ferritin in early pregnancy is strongly associated with GDM and insulin resistance but not gestational dyslipidemia, raising questions about the necessity of routine iron supplementation during pregnancy.