Disease's type
GDM
Experimental grouping
GDM(n=960),Normal Glucose Tolerance(n=73649)
GPT's summary
This cohort study investigated the association between serum uric acid (UA) levels during early pregnancy and the risk of gestational diabetes mellitus (GDM) in 85,609 pregnant women in Shanghai, China. The prevalence of GDM was 14.0%. A non-linear relationship between serum UA levels and GDM risk was observed, with elevated UA levels at 13–18 weeks gestation significantly increasing GDM risk. Compared to the lowest UA quintile, the odds ratios for GDM were 1.11, 1.27, 1.37, and 1.70 for the second to fifth quintiles, respectively. The association was stronger in women aged 35 years or older. These findings suggest that higher serum UA levels at 13–18 weeks gestation are a risk factor for GDM, underscoring the importance of monitoring UA levels during this period for early prevention and intervention of GDM.
RF's name
Serum Uric Acid
Sample's type
Serum
Gestational weeks
before 12th gestational weeks
Experiemental methods
Enzymatic methods
Machine learning algorithms
Logistic Regression
Title
Serum uric acid in early pregnancy and risk of gestational diabetes mellitus: A cohort study of 85,609 pregnant women
Evidence's type
Risk factor
Year
2022
Journal
Diabetes & Metabolism Journal
PMID