Disease's type
GDM
Experimental grouping
GDM(n=1744),Normal Glucose Tolerance(n=4256);UA:Q1(153.81±18.22)Q2(191.60±8.62)Q3(222.44±10.03)Q4(285.41±43.72μmol/L)
GPT's summary
This study explored the relationship between first-trimester serum uric acid (UA) levels and the risk of gestational diabetes mellitus (GDM). Among 1744 GDM patients and 4256 with normal glucose tolerance (NGT), higher UA levels were associated with an increased risk of GDM. As UA quartiles increased, the GDM rate rose, and fasting plasma glucose, 1-hour, and 2-hour post-glucose levels also increased significantly (P < 0.05). Logistic regression analysis identified UA as an independent risk factor for GDM, with a predictive threshold of 226.55 μmol/L for GDM. The findings suggest that higher first-trimester UA levels are associated with GDM and could be a valuable indicator for early risk prediction and prevention strategies.
RF's name
Serum Uric Acid
Sample's type
Serum
Gestational weeks
8th to 12th gestational weeks
Experiemental methods
Enzymatic methods
Title
New perspective on first-trimester serum uric acid level in predicting the risk of gestational diabetes mellitus
Evidence's type
Risk factor
Year
2024
Journal
Scientific Reports
PMID