UA

This prospective double-center study investigated the relationship between serum uric acid (UA) levels in early pregnancy and the risk of gestational diabetes mellitus (GDM) in 873 pregnant women in Beijing, China. The incidence of GDM was 20.27%. Compared to non-pregnant women, serum UA and creatinine levels significantly decreased during early pregnancy. However, serum UA levels were significantly higher in GDM women than in those with normal glucose tolerance (217.0 vs. 201.9 μmol/L, p < 0.001). After adjusting for confounders, elevated serum UA remained an independent risk factor for GDM, with an adjusted odds ratio of 1.964 for UA levels above 240 μmol/L (p < 0.001). The association between UA and GDM was stronger in women over 35 years old and those with pre-pregnancy BMI ≥ 24 kg/m2. The study highlights the importance of monitoring serum UA levels in early pregnancy, especially in older and overweight women, to predict and prevent GDM.