PAPP-A

This study investigated whether first-trimester biochemical markers of placentation, including pregnancy-associated plasma protein-A (PAPP-A) and placental growth factor (PLGF), are altered in women who develop gestational diabetes mellitus (GDM) and their potential role in improving GDM screening. Among 31,225 singleton pregnancies, including 787 GDM cases, PAPP-A levels were slightly reduced (median 0.949 MoM, p=0.0009), and PLGF levels were slightly increased (median 1.053 MoM, p=0.004) in the GDM group compared to unaffected pregnancies. However, adding PAPP-A and PLGF levels to maternal factors did not improve the performance of GDM screening based on receiver operating characteristic (ROC) curves. The study concludes that first-trimester PAPP-A and PLGF are not useful markers for GDM screening.