Disease's type
GDM
Experimental grouping
GDM(n=18),Normal Glucose Tolerance(n=253)
GPT's summary
This study aimed to predict gestational diabetes mellitus (GDM) during the first trimester by evaluating fasting glucose, insulin levels, and the homeostasis model assessment-insulin resistance (HOMA-IR) index in 271 pregnant women between 10-14 weeks of gestation. Results showed that HOMA-IR values were significantly higher in women who developed GDM. A HOMA-IR cut-off value of 2.60 was identified as predictive for GDM. The study concludes that using a HOMA-IR threshold of >2.60 in the first trimester could be an effective method for early prediction of GDM.
RF's name
Homeostatic Model Assessment of Insulin Resistance
Sample's type
Serum
Gestational weeks
10th to 14th gestational weeks
Experiemental methods
Hexokinase Method & CLIA
Title
Diagnosis of gestational diabetes mellitus by use of the homeostasis model assessment-insulin resistance index in the first trimester
Evidence's type
Risk factor
Year
2008
Journal
Gynecological Endocrinology
PMID