Lep

This study investigated the role of first-trimester leptin, resistin, and visfatin levels in predicting gestational diabetes mellitus (GDM) among 70 women who developed GDM and 70 controls. Women who later developed GDM exhibited significantly higher levels of leptin, resistin, and visfatin, along with dyslipidemia, compared to those without GDM (p < 0.05). The predictive value of these adipokines was strong, with areas under the ROC curves (AUCs) of 0.812, 0.836, and 0.799 for leptin, resistin, and visfatin, respectively. Increased leptin (OR = 1.166, CI = 1.104–1.233, p < 0.0001), resistin, and visfatin levels were independently associated with GDM. The study concludes that elevated levels of these adipokines in the first trimester may serve as reliable predictive markers for GDM.