Ins

This study investigated whether elevated serum insulin levels in early pregnancy (before 16 weeks) could predict gestational diabetes mellitus (GDM) in high-risk women. Among 71 participants, fasting and 120-min post-OGTT insulin levels were strong predictors of GDM. At gestation weeks 24-28, fasting and 120-min insulin levels had sensitivities of 69.2% and 92.3% and specificities of 96.4% and 85.7%, respectively. Their negative predictive values were 0.87 and 0.96, while their odds ratios for predicting GDM at weeks 32-34 were 16.6 and 13.3, respectively. The study concludes that early pregnancy serum insulin determination is an effective and reliable method for predicting GDM in high-risk women. Even with a negative OGTT, elevated insulin levels warrant GDM management, while normal levels may justify delaying OGTT to later gestation.