TPOAb

This study examined the relationship between thyroid markers during pregnancy and the risk of gestational diabetes mellitus (GDM) as well as post-partum glucose metabolism. Among 1467 pregnant women, the GDM group exhibited higher levels of free triiodothyronine (FT3), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) in the first trimester, and higher TPOAb and TgAb but lower free thyroxine (FT4) levels in the second trimester compared to the normal glucose tolerance (NGT) group. FT3, TPOAb, and TgAb in the first trimester, as well as FT4, TPOAb, and TgAb in the second trimester, were identified as risk factors for GDM. Post-partum, higher TPOAb and TgAb levels were associated with abnormal glucose tolerance (AGT). The findings indicate that altered thyroid markers during pregnancy, particularly thyroid antibodies, are associated with increased GDM risk and can predict post-partum glucose abnormalities in GDM patients.