TPOAb

Leptin, an adipocyte-derived hormone, plays a crucial role in regulating immune responses, particularly T-lymphocyte activity, and its function is tightly linked to nutritional status. In this study, we demonstrate that leptin specifically modulates T-cell responses by enhancing the proliferation of naive T cells while suppressing memory T cell function. Additionally, leptin promotes Th1 cytokine production and inhibits Th2 cytokines, suggesting its role in shaping the immune response. Under conditions of acute starvation, leptin administration effectively counteracts the immunosuppressive effects, indicating its potential as a key mediator in linking nutritional status to immune function. These findings provide new insights into the molecular mechanisms underlying immune dysfunction during nutritional deprivation and highlight leptin’s pivotal role in maintaining immune homeostasis.