Disease's type
GDM
Experimental grouping
4746 pregnant women, NICE-GDM(n=538),IADPSG-GDM(n=633)
GPT's summary
This study found that low vitamin B12 and high folate levels in early pregnancy were associated with an increased risk of gestational diabetes mellitus (GDM). While B12 insufficiency (42.3%) and folate excess (36.5%) were common, a combination of low B12 and high folate further elevated GDM risk. Higher B12 levels were linked to reduced GDM risk, while higher folate levels were associated with increased risk. These findings highlight the need for further research on optimizing B12 and folate levels in early pregnancy to reduce GDM risk.
RF's name
Folate
Sample's type
Serum
Gestational weeks
before 12.5 gestational weeks
Experiemental methods
Electro-Chemiluminescent Immunoassay
Title
Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study)
Evidence's type
Risk factor
Year
2021
Journal
Diabetologia
PMID