Disease's type
GDM
Experimental grouping
GDM(n=444),Normal Glucose Tolerance(n=1767),assigned to quintile groups according serum FT4 levels
GPT's summary
This study investigated the relationship between thyroid function and the risk of gestational diabetes mellitus (GDM) in assisted pregnancies, analyzing data from 2211 pregnant women. The prevalence of GDM was 20.1%. Lower FT4 levels were initially associated with increased GDM risk, but this association disappeared after adjustments. However, thyroid peroxidase antibody positivity (TPOAb+) independently increased GDM risk (adjusted OR = 1.472). Among TPOAb+ patients, higher TSH (adjusted OR = 2.882) and lower FT4 (adjusted OR = 3.156) levels were significantly associated with GDM risk. The findings suggest that TPOAb+ status, along with thyroid hormone imbalances, is a key risk factor for GDM in assisted pregnancies.
RF's name
Thyroid Hormone
Sample's type
Serum
Gestational weeks
first antenatal visit
Experiemental methods
CLIA
Title
Association between thyroid function and risk of gestational diabetes mellitus in assisted pregnancies: A retrospective cohort study
Evidence's type
Risk factor
Year
2021
Journal
Diabetes Research And Clinical Practice
PMID