Disease's type
GDM
Experimental grouping
SF(Lowest)fT4(Lowest), N=91(1.39%);SF(Highest)fT4(Lowest), N=65(0.99%);SF(Normal)fT4(Lowest), N=204(3.12%);SF(Lowest)fT4(Normal), N=1465(22.39%);SF(Highest)fT4(Normal), N=1581(24.17%);SF(Normal)fT4(Normal), N=3136(47.94%)
GPT's summary
This study aimed to investigate the combined effect of serum ferritin (SF) concentration and free thyroxine (fT4) levels on the risk of gestational diabetes mellitus (GDM) in early pregnancy. Data from 6542 pregnant women were analyzed. High SF levels were associated with an increased risk of GDM (OR = 1.21, 95% CI: 1.02–1.43), while low fT4 levels were not significantly associated with GDM risk (OR = 1.18, 95% CI: 0.89–1.58). Additionally, there was no evidence of an additive interaction between SF and fT4 levels on GDM development. The study concludes that high SF concentration in early pregnancy increases the risk of GDM, while fT4 levels do not influence this association.
RF's name
Thyroid Hormone
Sample's type
Serum
Gestational weeks
first antenatal visit
Experiemental methods
CLIA
Title
Do free thyroxine levels influence the relationship between maternal serum ferritin and gestational diabetes mellitus in early pregnancy?
Evidence's type
Risk factor
Year
2019
Journal
Diabetes Research And Clinical Practice
PMID