Disease's type
GDM
Experimental grouping
GDM(n=3697),Normal Glucose Tolerance(n=23816)
GPT's summary
This study investigated the relationship between thyroid hormone levels in early pregnancy and the risk of gestational diabetes mellitus (GDM) in a cohort of 27,513 mothers. The results showed that GDM incidence increased with maternal age, higher prepregnancy body mass index (BMI), and a family history of diabetes. Notably, women who developed GDM had significantly lower levels of free T4 (FT4) in early pregnancy compared to non-GDM women. A negative correlation was observed between early pregnancy FT4 levels and GDM incidence, indicating that lower thyroid hormone levels in early pregnancy are a risk factor for GDM.
RF's name
Thyroid Hormone
Sample's type
Serum
Gestational weeks
9th to 13th gestational weeks
Experiemental methods
Chemiluminescent Microparticle Immunoassays
Title
Low Thyroid Hormone in Early Pregnancy Is Associated With an Increased Risk of Gestational Diabetes Mellitus
Evidence's type
Risk factor
Year
2016
Journal
Journal of Clinical Endocrinology & Metabolism
PMID