Disease's type
GDM
Experimental grouping
GDM(n=258),Normal Glucose Tolerance(n=1154);lowest group (<5.30 × 10^9/L), middle group (5.30–6.80 × 10^9/L), and highest group (>6.80 × 10^9/L)
GPT's summary
This study explored the predictive role of inflammatory blood cell parameters in gestational diabetes mellitus (GDM) and pregnancy outcomes in a cohort of 258 women with GDM and 1,154 without. Among the parameters analyzed, first-trimester neutrophil count demonstrated superior predictive ability for GDM compared to total white blood cell count and the neutrophil-to-lymphocyte ratio. Higher neutrophil counts were associated with a stepwise increase in GDM incidence, glucose and glycosylated hemoglobin levels, HOMA-IR, macrosomia incidence, and newborn weight. Neutrophil count was positively correlated with prepregnancy BMI, insulin resistance (HOMA-IR), and newborn weight and was identified as an independent risk factor for GDM development, irrespective of a prior GDM history. A significant linear association between GDM risk and neutrophil count was observed when the neutrophil count exceeded 5.0 × 10?/L. These findings highlight the potential utility of first-trimester neutrophil count as an early biomarker for GDM and its associated adverse pregnancy outcomes.
RF's name
Absolute Neutrophil Count
Sample's type
Whole Blood
Gestational weeks
first antenatal visit
Experiemental methods
Flow Cytometry & fluorescent labeling
Title
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
Evidence's type
Risk factor
Year
2020
Journal
Diabetes
PMID