ANT

This study investigated the predictive value of first-trimester maternal neutrophil levels for gestational diabetes mellitus (GDM) in a cohort of 731 singleton pregnant women. Neutrophil count was found to outperform other inflammatory markers, such as the neutrophil-to-lymphocyte ratio and white blood cell count, in predicting GDM. After adjusting for pre-pregnancy BMI, family history of diabetes, and age, higher neutrophil counts were associated with increased fasting and 1-hour postprandial blood glucose levels. Logistic regression analysis revealed that women in the highest tertile of neutrophil count (6.28–14.73 × 10?/L) had a 1.85-fold higher risk of developing GDM compared to those in the lowest tertile (1.47–4.82 × 10?/L). These findings suggest that elevated neutrophil levels in early pregnancy are associated with an increased risk of GDM and could serve as a useful early predictive marker.