RC

This study examined the relationship between serum remnant cholesterol (RC) levels at 12–14 weeks of gestation and the risk of gestational diabetes mellitus (GDM) in a cohort of 590 pregnant women in Korea. The analysis revealed that RC was positively associated with the risk of GDM, with an adjusted odds ratio of 1.458 (95% CI: 1.221–1.741). Notably, other lipoprotein cholesterol parameters, including total cholesterol (TC), LDL-c, and HDL-c, were not significantly associated with GDM risk. The area under the ROC curve (AUC) for RC as a predictor of GDM was 0.8038, with an optimal cut-off value of 24.30 mg/dL. Pregnant women with RC levels above this threshold were identified as having a higher risk of developing GDM. These findings suggest that RC in early pregnancy could serve as an early and effective biomarker for GDM, particularly in women with normal HDL-c, LDL-c, and TC levels, who might otherwise be overlooked. This study underscores the importance of incorporating RC measurement into early pregnancy evaluations to enhance GDM prevention and management strategies.