Disease's type
GDM
Experimental grouping
GDM(n=1177),Normal Glucose Tolerance(n=4718),assigned to quintile groups according serum FT3 levels
GPT's summary
This study investigated the relationship between first-trimester thyroid hormone indices, pre-pregnancy BMI, and gestational diabetes mellitus (GDM) risk in 5895 pregnant women. Low FT4, high FT3-to-FT4 ratio, and low TFQI were associated with increased GDM risk. Thyroid biomarkers also mediated 24.9% of the effect of pre-pregnancy BMI on GDM risk, suggesting that thyroid function influences glucose metabolism and contributes to GDM development. These findings highlight the importance of monitoring thyroid function and BMI in early pregnancy to identify women at higher risk for GDM and guide early intervention strategies.
RF's name
Free Triiodothyronine
Sample's type
Serum
Gestational weeks
before 12th gestational weeks
Experiemental methods
Chemiluminescent Immunoassay
Title
Effects of thyroid hormones modify the association between pre-pregnancy obesity and GDM: evidence from a mediation analysis
Evidence's type
Risk factor
Year
2024
Journal
Frontiers in Endocrinology
PMID