Res

This study investigated the roles of adipokines (leptin, resistin, and visfatin) and lipid profiles in predicting gestational diabetes mellitus (GDM) during the first trimester. Significant elevations in leptin, resistin, and visfatin levels, as well as dyslipidemia, were observed in women who later developed GDM compared to those who did not. The predictive accuracy for GDM, reflected by the area under the receiver operating characteristic curves (AUCs), was 0.812 for leptin, 0.836 for resistin, and 0.799 for visfatin. Elevated leptin (OR = 1.166), resistin, and visfatin levels were strongly associated with GDM risk. These findings suggest that hyperleptinemia, hyperresistinemia, and hypervisfatinemia during early pregnancy can serve as effective biomarkers for early prediction and prevention of GDM.