Res

This study investigated the role of adipocytokines (adiponectin, resistin, interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-alpha]) as potential predictive markers of gestational diabetes mellitus (GDM). Pregnant women with normal BMI were recruited at 12–14 weeks of gestation and monitored until 24–28 weeks. Blood samples were analyzed for adipocytokines, insulin, and glucose levels to calculate insulin resistance (HOMA-IR). Results showed significantly higher levels of HOMA-IR, resistin, IL-6, and TNF-alpha, and lower levels of adiponectin in GDM subjects compared to healthy controls, both at 12 and 24 weeks. Additionally, adipocytokine levels changed significantly from 12 to 24 weeks in both groups, with increases in resistin, IL-6, and TNF-alpha, and a decrease in adiponectin. These findings suggest that adipocytokines play a role in the pathophysiology of GDM and could serve as early predictive markers for its development.