Disease's type
GDM
Experimental grouping
GDM(n=1688),Normal Glucose Tolerance(n=7480)(ALT,Q1:1-10U/L,Q2:11-13U/L,Q3:14-19U/L,Q4:20-87U/L)
GPT's summary
This study investigated the relationship between liver function biomarkers in early pregnancy and the risk of gestational diabetes mellitus (GDM) in a cohort of 9,148 pregnant women. Elevated levels of liver function indices (ALT, AST, GGT, ALP, and hepatic steatosis index) were significantly associated with an increased risk of GDM, particularly abnormal postprandial glucose levels. Among these, a causal link between ALT and GDM was confirmed using Mendelian randomization analysis (OR=1.28). Furthermore, a significant interaction between AST/ALT ratio and triglycerides (TG) on GDM risk was identified. These findings highlight the potential role of liver biomarkers as predictors of GDM and suggest a need for further exploration of liver function's impact on glucose metabolism during pregnancy.
RF's name
Alanine Aminotransferase
Sample's type
Serum
Gestational weeks
8th to 14th gestational weeks
Experiemental methods
Enzymatic Methods
Title
The associations of maternal liver biomarkers in early pregnancy with the risk of gestational diabetes mellitus: a prospective cohort study and Mendelian randomization analysis
Evidence's type
Risk factor
Year
2024
Journal
Frontiers in Endocrinology
PMID