FABP4

This study aimed to evaluate the diagnostic potential of fatty acid-binding protein 4 (FABP4) in gestational diabetes mellitus (GDM) and to explore its associations with overweight, insulin resistance, and inflammatory marker TNF-α. Among 46 women with GDM and 55 age-matched non-GDM women, serum FABP4 levels were significantly higher in the GDM group. ROC curve analysis demonstrated a strong predictive value of FABP4 for GDM, with an area under the curve (AUC) of 0.94. A cutoff value of 1.96 ng/mL provided an optimal balance between specificity (86.96%) and sensitivity (89.09%). FABP4 levels were positively correlated with overweight, insulin resistance, and TNF-α in GDM patients. These findings suggest that FABP4 could be a promising biomarker for early prediction and diagnosis of GDM, offering a potential tool for risk assessment and targeted intervention.