FABP4

Fatty acid-binding protein 4 (FABP4), predominantly expressed in adipocytes, monocytes, and macrophages, plays a crucial role in lipid metabolism, immune regulation, and insulin signaling. Its dysregulation has been implicated in obesity, insulin resistance, type 2 diabetes, cardiovascular disease, and cancer. Elevated FABP4 levels in individuals with obesity (BMI >30) highlight its role in metabolic dysfunction, both in tissues and circulation, where it contributes to systemic inflammation and tumorigenesis. Recent research suggests that FABP4 inhibition could serve as a promising therapeutic strategy for obesity-related diseases, particularly insulin resistance and diabetes. However, given its extensive involvement in metabolic and inflammatory pathways, further studies are required to assess potential side effects before clinical translation. This review provides a comprehensive overview of FABP4’s biological functions and therapeutic potential, offering new perspectives for targeted interventions in metabolic syndrome and related disorders.