FABP4

Lipids play a fundamental role in cellular processes and disease pathogenesis, yet the mechanisms linking intracellular lipids to biological targets and signaling pathways remain poorly understood, particularly in lipid-rich cells like adipocytes and macrophages. Fatty acid-binding proteins (FABPs) function as critical lipid chaperones, mediating lipid trafficking, signaling, and metabolic regulation. By influencing diverse lipid signals, FABPs contribute to systemic metabolic homeostasis and inflammatory responses. Emerging pharmacological strategies targeting FABPs hold promise for selectively modulating lipid signaling in specific tissues or cell types, offering a novel therapeutic avenue for metabolic diseases such as obesity, diabetes, and atherosclerosis.