TG to HDL-C ratio

This study aimed to develop a simplified screening model to identify pregnant Chinese women at risk of gestational diabetes mellitus (GDM) in the first trimester. The study included 1,289 pregnant women and utilized logistic regression to select predictors, including maternal age, prepregnancy body mass index (BMI), family history of diabetes, fasting blood glucose, the alanine transaminase to aspartate aminotransferase ratio (ALT/AST), and the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C). The model demonstrated good performance in both discrimination and calibration, with a receiver operating characteristic area under the curve (ROC-AUC) of 0.825 for the logistic regression model and 0.784 for the simplified model. The model outperformed three other published models. This simplified screening model provides a practical tool for early identification of women at high risk of GDM, though further validation is needed in other populations.