TG to HDL-C ratio

This study aimed to assess the potential of early pregnancy lipid ratios and the Triglyceride Glucose Index (TyG) in predicting Gestational Diabetes Mellitus (GDM). A total of 1,073 singleton pregnant women were enrolled, and lipid profiles along with a 75g oral glucose tolerance test (OGTT) at 24-28 weeks were performed. Results showed that women with GDM had higher levels of TyG, TG/HDL-C, and LDL-C/HDL-C, with TyG emerging as an independent risk factor for insulin resistance. The TyG index demonstrated an Area Under the Curve (AUC) of 0.692, comparable to that of HOMA-IR (0.703). TyG, TG/HDL-C, and HOMA-IR showed specific cut-off points for predicting GDM. The study concluded that early pregnancy TyG index and TG/HDL-C are useful tools for identifying women at risk for GDM, with TyG showing superior predictive capability.