CHO

This study aimed to investigate the role of lipid profiles and inflammatory biomarkers in the pathogenesis of gestational diabetes mellitus (GDM). A cohort of 300 pregnant women was selected, including 176 with a positive family/clinical history of GDM and 124 without such a history, with blood samples taken during the early second trimester (14-18 weeks of gestation). Follow-up samples were collected during the early third trimester (24-28 weeks). The results showed that women who later developed GDM had significantly higher levels of triglycerides, total cholesterol, low-density lipids (LDL), very low-density lipids (VLDL), and lower levels of high-density lipoprotein (HDL) in the early second trimester compared to those who did not develop GDM. Additionally, high-sensitivity C-reactive protein (hs-CRP) levels were 69% higher in those who developed GDM. Notably, 32% of the women who developed GDM had a positive clinical or family history. The study concluded that abnormal lipid profiles and elevated hs-CRP levels play an important role in the development of GDM, suggesting that early biochemical screening could help in the timely diagnosis of GDM and reduce adverse maternal and neonatal outcomes.