Vit B12

This study aimed to explore the association between early pregnancy levels of folate and vitamin B12 and the risk of gestational diabetes mellitus (GDM). The research was conducted using data from the Shanghai Preconception Cohort Study, which included pregnancies with red blood cell (RBC) folate and vitamin B12 measurements taken between 9 and 13 weeks of gestation. GDM was diagnosed between 24 and 28 weeks. The study found that both RBC folate and vitamin B12 levels were significantly higher in pregnancies that developed GDM compared to those without GDM, and these biomarkers were positively correlated with 1-hour and 2-hour serum glucose levels. Daily folic acid supplementation in early pregnancy was associated with an increased risk of GDM, with an odds ratio (OR) of 1.73. Pregnancies with RBC folate levels ≥600 ng/mL had a 1.60-fold higher odds of GDM compared to those with RBC folate levels <400 ng/mL. Additionally, each 100 pg/mL increase in vitamin B12 was associated with a 1.14-fold increase in GDM risk. However, no significant association was found between the balance of folate to vitamin B12 or serum folate levels and GDM. The findings suggest that higher maternal RBC folate and vitamin B12 levels in early pregnancy are significantly associated with an increased risk of GDM.