Vit B12

This study aimed to assess the association between maternal B vitamins in early pregnancy and the risk of gestational diabetes mellitus (GDM). A cohort of 1,265 pregnant women was recruited between 8 to 15 weeks of gestation in Shanghai, China, in 2021-2022. The final analysis included 1,065 pregnancies with both serum B vitamin measurements at recruitment and glucose measurements at 24-28 weeks of gestation. The study found that GDM occurred in 121 women (11.36%). Multivariate logistic regression models showed an increasing risk of GDM across serum vitamin B1 quartiles (p-Trend = 0.001). Women in the upper two quartiles of serum vitamin B6 had about twice the odds of developing GDM compared to those in the lowest quartile. Conversely, women with serum vitamin B12 levels greater than 150 pmol/L had lower odds of GDM compared to those with levels less than 150 pmol/L (p = 0.005). Restricted cubic spline regression models indicated that serum vitamin B6 and B12 were associated with GDM risk in a nonlinear fashion. In conclusion, the study found that higher maternal serum levels of vitamin B1 and B6 in early pregnancy were linked to an increased risk of GDM, while sufficient vitamin B12 levels were associated with a lower risk.