Disease's type
GDM
Experimental grouping
GDM(n=2973),Normal Glucose Tolerance(n=10475);BUN levels: Q1=3209, <2.40 mmol/L; Q2=3509, ≥2.40 and <2.91 mmol/L; Q3=3225, ≥2.91 and <3.50 mmol/L; and Q4=3505, ≥3.50 mmol/L
GPT's summary
This study aimed to investigate the association between blood urea nitrogen (BUN) levels in the first trimester of pregnancy and the risk of developing gestational diabetes mellitus (GDM). Conducted as a prospective multicenter cohort study, the analysis included 13,448 pregnant women with measured first-trimester BUN levels. Logistic regression was used to estimate the relationship between BUN and GDM risk, and the potential for BUN to improve discrimination and reclassification of GDM risk was assessed. The study found that 2,973 women (22.1%) developed GDM. Compared with women in the lowest quartile of BUN, those in the third and fourth quartiles had significantly higher risks of GDM, with adjusted odds ratios of 1.21 (95% CI: 1.07-1.37) and 1.50 (95% CI: 1.33-1.69), respectively (P for trend < 0.001). Adding BUN levels to conventional models improved GDM risk prediction, with a 0.2% increase in the C-statistic, and a net reclassification index of 14.67% (P < 0.001). The findings suggest that higher BUN concentrations in early pregnancy are associated with an increased risk of GDM, making BUN a potential predictor for the condition.
RF's name
Blood Urea Nitrogen
Sample's type
Serum
Gestational weeks
around 14 gestational weeks
Experiemental methods
Urea (BUN) Colorimetric Assay Kit
Machine learning algorithms
Logistic Regression
Title
First-trimester blood urea nitrogen and risk of gestational diabetes mellitus
Evidence's type
Risk factor
Year
2020
Journal
Journal of Cellular And Molecular Medicine
PMID