SCHE

This study aimed to investigate the association between chemerin levels in the first trimester of pregnancy and the risk of gestational diabetes mellitus (GDM). Blood samples were collected from 212 pregnant women at 8-12 weeks of gestation. The study included 19 women diagnosed with GDM and 20 women randomly selected from 144 women with normal glucose tolerance (NGT). Key biomarkers, including triglycerides, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, insulin, and chemerin, were measured. Gestational weight gain and body mass index (BMI) were also assessed. The results showed that serum levels of chemerin were significantly elevated in women later diagnosed with GDM. The study found a positive association between maternal serum chemerin levels in the first trimester and the risk of developing GDM. In conclusion, chemerin levels during the first trimester may serve as a potential predictor for the risk of GDM.