NAMPT

This case-control study aimed to evaluate the potential of maternal serum visfatin and adiponectin concentrations in early pregnancy as biomarkers for predicting gestational diabetes mellitus (GDM). The study included 100 women who developed GDM and 300 nondiabetic controls. Serum concentrations of visfatin and adiponectin were measured between 11 and 13 weeks of gestation. Regression analysis was conducted to identify maternal characteristics affecting these biomarkers. The results showed that compared to the nondiabetic group, women with GDM had significantly higher levels of visfatin (1.34 MoM) and lower levels of adiponectin (0.66 MoM). Screening for GDM by combining maternal factors with these biomarkers resulted in a detection rate of 68% at a false-positive rate of 10%. The study concluded that serum visfatin and adiponectin levels in early pregnancy, when combined with maternal factors, could provide effective early screening for GDM.