NAMPT

This case-case control study aimed to determine whether serum leptin, resistin, and visfatin levels in the first trimester are altered in pregnancies that develop gestational diabetes mellitus (GDM) and whether these changes can predict the disease. The study compared the biochemical and anthropometric parameters of 70 pregnant women who later developed GDM with 70 women who did not, at the Volta Regional Hospital in Ghana. The results showed significant differences in leptin, resistin, and visfatin levels, as well as dyslipidemia, between the two groups (p < 0.05). The area under the Receiver Operating Characteristic Curves (AUCs) for leptin, resistin, and visfatin were 0.812, 0.836, and 0.799, respectively. Increased levels of leptin (OR = 1.166), resistin, and visfatin were strongly associated with GDM (all p < 0.0001). The study concluded that elevated levels of leptin, resistin, and visfatin in the first trimester could serve as useful predictive biomarkers for GDM.