Disease's type
GDM
Experimental grouping
GDM(n=48),Normal Glucose Tolerance(n=225)
GPT's summary
This study investigated the dysregulation of adipokines and monocyte/macrophage markers in gestational diabetes mellitus (GDM) and their potential for early detection. It found that sCD163 levels were elevated and adiponectin levels decreased in women with GDM, independent of BMI. Additionally, markers like leptin and adiponectin were associated with glucose metabolism throughout pregnancy. While sCD163 showed modest predictive value for GDM when combined with fasting glucose, no single marker provided clinically useful early detection on its own. The study suggests that monocyte/macrophage activation might play a crucial role in the early development of GDM.
RF's name
Soluble CD163 antigen
Sample's type
Plasma
Gestational weeks
14th to 16th gestational weeks
Experiemental methods
ELISA
Machine learning algorithms
Logistic Regression
Title
Adipokines and macrophage markers during pregnancy-Possible role for sCD163 in prediction and progression of gestational diabetes mellitus
Evidence's type
Risk factor
Year
2019
Journal
J Endocrinol Invest
PMID