MPV

This study evaluated the predictive value of increasing inflammatory markers for gestational diabetes mellitus (GDM). A cross-sectional study of 302 GDM cases and 310 normal pregnancies before 20 weeks gestation was conducted. Sociodemographic, pregnancy characteristics, and blood parameters were collected from maternal health booklets, medical records, and laboratory systems. Independent sample t-tests compared blood cell parameters between groups, while multivariate logistic regression, χ2-tests, receiver operating characteristic (ROC) curves, and Fisher’s linear discriminant analysis assessed the variables' screening effectiveness for GDM. The results showed that neutrophil (NEU), lymphocyte (LYM), platelet (PLT), and erythrocyte (RBC) counts were significantly higher in women with GDM and positively correlated with its development. NEU (odds ratio [OR]: 1.22) and LYM (OR: 2.01) were independently associated with GDM (P < 0.001). In contrast, mean platelet volume (MPV) and mean cell volume (MCV) were inversely associated with GDM risk (ORs: 0.84 and 0.92, respectively; P < 0.01). Fisher’s equation demonstrated a 70.06% accuracy in classifying GDM cases from 4 to 20 weeks gestation. These findings underscore the importance of maternal WBC, RBC, and PLT counts as correlates of GDM, while increased RBC and PLT volumes may provide protective effects against GDM development.