MPV

This study investigated the potential of early pregnancy platelet parameters to predict gestational diabetes mellitus (GDM) in 1188 singleton pregnant women without pre-pregnancy diabetes or other complications. Platelet parameters, including platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), were measured at 11–13+6 weeks, and their association with GDM was analyzed. Results indicated that MPV and PCT were significantly correlated with GDM risk after adjusting for factors like age, parity, and pre-pregnancy BMI (p < 0.05). The area under the curve (AUC) for MPV was 0.577 (95% CI: 0.533–0.621), and for PCT, it was 0.628 (95% CI: 0.582–0.674), suggesting a moderate predictive value. However, PLT and PDW showed no significant association with GDM. These findings suggest that MPV and PCT in early pregnancy could serve as potential indicators for predicting GDM, providing a basis for early screening and intervention.