K

This study examined the relationship between potassium levels during the first half of pregnancy and the risk of developing gestational diabetes mellitus (GDM) and hypertensive disorders, including severe pre-eclampsia, in the second half of pregnancy. Data from 8,114 deliveries between 2001 and 2007 were analyzed, with potassium levels categorized as <3.5 mEq/L, 3.5–3.99 mEq/L, and ≥4.0 mEq/L. The findings revealed a significant linear association between potassium levels and GDM prevalence: 6.3% for <3.5 mEq/L, 6.6% for 3.5–3.99 mEq/L, and 8.2% for ≥4.0 mEq/L (p = 0.008). A similar trend was observed for severe pre-eclampsia: 0.4% for <3.5 mEq/L, 0.9% for 3.5–3.99 mEq/L, 1.3% for 4.0–4.99 mEq/L, and 1.5% for ≥5 mEq/L (p = 0.027). Potassium levels ≥5 mEq/L were identified as a significant risk factor for both GDM and severe pre-eclampsia. Multiple logistic regression models controlling for maternal age confirmed that elevated potassium levels were independent risk factors for these pregnancy complications. These results highlight the potential role of early-pregnancy potassium levels in identifying women at risk for GDM and severe pre-eclampsia.