Nes-1

This study investigated the potential roles of serum nesfatin-1 and vaspin levels as biomarkers for the prediction and early diagnosis of gestational diabetes mellitus (GDM). Serum concentrations of nesfatin-1 and vaspin were measured in 153 women with GDM and 84 women with uncomplicated pregnancies using enzyme-linked immunosorbent assay (ELISA). The results showed that circulating levels of nesfatin-1 and vaspin were significantly lower in women with GDM compared to the control group. Moreover, nesfatin-1 levels were negatively correlated with vaspin levels. These findings suggest that nesfatin-1 and vaspin could serve as potential novel biomarkers for GDM risk assessment and early diagnosis. However, further research is required to understand their influence on glucose metabolism during the early stages of GDM.