AMT

This prospective study explored the associations between inflammatory blood cell parameters during early and middle pregnancy, as well as their change patterns, and the risk of gestational diabetes mellitus (GDM) in a cohort of 6,354 pregnant women. Among the participants, 445 were diagnosed with GDM. Results showed that elevated levels of white blood cells (WBC), neutrophils, lymphocytes, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in early pregnancy were positively associated with increased GDM risk. Extreme-quartile comparisons revealed odds ratios (95% CI) of 2.38 (1.76–3.20) for WBC, 2.47 (1.82–3.36) for neutrophils, 1.40 (1.06–1.85) for lymphocytes, 1.69 (1.27–2.24) for monocytes, and 1.51 (1.12–2.02) for NLR, all with significant trends (P ≤ .010).Similarly, elevated levels of WBC, neutrophils, monocytes, and NLR in middle pregnancy were associated with higher GDM risk (all P ≤ .014). Women with stable high levels (≥ median in both early and middle pregnancy) of these parameters demonstrated significantly increased GDM risk (all P ≤ .001). These findings highlight the clinical relevance of monitoring inflammatory blood cell parameters as potential early indicators of GDM risk, emphasizing their utility in identifying high-risk individuals for timely interventions.