sPRR

This study investigated the association between plasma soluble (pro)renin receptor [s(P)RR] concentrations during early pregnancy and the risk of gestational diabetes mellitus (GDM) in a prospective cohort of 716 pregnant women without preexisting diabetes. Among the participants, 44 (6.1%) developed GDM. Plasma s(P)RR concentrations were divided into quartiles (Q1: <25.8 ng/mL, Q4: >34.2 ng/mL), with GDM prevalence increasing across quartiles: 4.0% in Q1, 2.8% in Q2, 7.2% in Q3, and 10.6% in Q4. Multivariate analysis revealed that women in the highest quartile (Q4) had a 2.90-fold increased risk of developing GDM compared to those in the lowest quartile (Q1) (95% CI: 1.11–7.49). These findings suggest that elevated plasma s(P)RR concentrations during the first trimester may serve as a predictive biomarker for GDM later in pregnancy.