Hct

This study assessed the diagnostic accuracy of multiple complete blood count (CBC) indicators for the early prediction of gestational diabetes mellitus (GDM) in a prospective cohort of 600 pregnant women. Among the participants, 49 (8.2%) were diagnosed with GDM at 24–28 weeks of gestation using a two-step diagnostic approach. Analysis revealed that in the first and early second trimesters, women with GDM had significantly higher mean hematocrit (Hct), hemoglobin (Hb), fasting blood sugar (FBS), and red blood cell count (RBC) compared to non-GDM women (P < 0.001). A predictive model combining repeated measures of Hct, Hb, RBC, and FBS yielded a sensitivity of 87%, specificity of 70%, and an area under the curve (AUC) of 83%. These findings suggest that concurrent longitudinal tracking of these indicators could serve as a practical and effective tool for the early prediction of GDM during pregnancy.