ANGPTL8

Angiopoietin-like protein 8 (ANGPTL8), a secreted protein primarily expressed in the liver and adipose tissue, plays a critical role in regulating triglyceride (TG) clearance by inhibiting lipoprotein lipase (LPL) activity. Elevated levels of ANGPTL8 have been observed in various metabolic disorders, including type 2 diabetes mellitus (T2DM), obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD). Despite these associations, the direct pathogenic role of ANGPTL8 in these diseases remains unclear. This review examines the emerging functions of ANGPTL8 in regulating inflammation, tumorigenesis, circulatory diseases, and ectopic lipid deposition. These findings suggest that ANGPTL8 may have broader implications beyond its well-established role in glucose and lipid metabolism, offering new insights into its diverse effects across multiple disease pathways.