Disease's type
GDM
Experimental grouping
GDM(n=67),Normal Glucose Tolerance(n=299) Participants were divided into deficient and non-deficient groups based on vitamin D status [deficiency, 25(OH)D < 20 nmol/L and non-deficiency, 25(OH)D ≥ 20 nmol/L] or serum selenium levels (deficiency, < 70 μg/L and normal, ≥ 70 μg/L).
GPT's summary
This cohort study explores the impact of an unbalanced ratio of folate to vitamin B12 in early pregnancy on the risk of developing GDM, considering the influence of serum selenium status. The research found that while overall higher RBC folate/vitamin B12 ratios were not associated with increased GDM risk, women with both high RBC folate/vitamin B12 ratios and selenium deficiency had a significantly higher risk of GDM. These findings highlight the importance of assessing micronutrient status in early pregnancy and addressing deficiencies to potentially reduce GDM risk.
RF's name
Selenium
Sample's type
Serum
Gestational weeks
before 12th gestational weeks
Experiemental methods
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Machine learning algorithms
Logistic Regression
Title
The Association Between the Imbalance of Single-Carbon Nutrients in Early Pregnancy and Gestational Diabetes Mellitus Risk is Influenced by Serum Selenium Status: A Cohort Study
Evidence's type
Risk factor
Year
2023
Journal
Diabetes, Metabolic Syndrome and Obesity
PMID