AFM

The study investigates whether afamin, a vitamin E-binding protein, can serve as an early biomarker for predicting gestational diabetes mellitus (GDM). Afamin's concentration increases during pregnancy and is associated with insulin resistance and metabolic syndrome. Two cohorts were analyzed: one from the first trimester and another from the mid-trimester. The first-trimester cohort included 59 GDM patients and 51 controls, while the mid-trimester cohort included 105 women. Afamin concentrations were significantly higher in GDM patients, especially those requiring insulin treatment (iGDM). The findings suggest that afamin could be a promising early biomarker for GDM, but further research is needed to confirm its predictive value.