Disease's type
GDM
Experimental grouping
GDM(n=332),Normal Glucose Tolerance(n=664)
GPT's summary
The study investigates the relationship between serum fetuin-A levels during early pregnancy and the risk of developing gestational diabetes mellitus (GDM). It found that higher fetuin-A levels are linked to a greater risk of GDM, especially in women with a waist circumference under 80 cm. Despite this observational finding, Mendelian randomization did not support a causal relationship between fetuin-A and GDM.
RF's name
Fetuin-A
Sample's type
Serum
Gestational weeks
6th to 15th gestational weeks
Experiemental methods
Human Quantikine Enzyme-Linked Immunosorbent Assay Kits
Machine learning algorithms
Multivariable conditional logistic regression
Title
Serum Fetuin-A and Risk of Gestational Diabetes Mellitus: An Observational Study and Mendelian Randomization Analysis
Evidence's type
Risk factor
Year
2022
Journal
The Journal of Clinical Endocrinology & Metabolism
PMID